ethyl benzofuran-6-carboxylate

Base Information

• Chemical Name: ethyl benzofuran-6-carboxylate
• CAS No.: 1289646-90-7
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.199

Synonyms:ethyl benzofuran-6-carboxylate

Chemical Property of ethyl benzofuran-6-carboxylate

Chemical Property:

• Boiling Point: 274.0±13.0 °C(Predicted)
• Density: 1.183±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Ethylbenzofuran-6-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of ethyl benzofuran-6-carboxylate

There total 3 articles about ethyl benzofuran-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(E)-ethyl 2-ethynyl-3-(furan-2-yl)acrylate (1129633-50-6) → ethyl benzofuran-6-carboxylate (1289646-90-7)

Guidance literature:

With platinum(IV) chloride; In toluene; at 110 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol302437v

Reference yield:

ethyl 2-(1,3-dioxolan-2-yl)methyl-3-(furan-2-yl)acrylate (1289646-88-3) → ethyl benzofuran-6-carboxylate (1289646-90-7)

Guidance literature:

With phosphoric acid; water; In ethanol; at 20 - 50 ℃; for 22.5h;

Reference yield:

ethyl 4-formyl-3-hydroxybenzoate (126200-19-9) + (bromomethyl)triphenyl phosphonium bromide (1034-49-7) → ethyl benzofuran-6-carboxylate (1289646-90-7)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 0 - 5 ℃; for 1.5h; Inert atmosphere; Large scale;

upstream raw materials:

(E)-ethyl 2-ethynyl-3-(furan-2-yl)acrylate

ethyl 2-(1,3-dioxolan-2-yl)methyl-3-(furan-2-yl)acrylate

ethyl 4-formyl-3-hydroxybenzoate

(bromomethyl)triphenyl phosphonium bromide

Downstream raw materials:

benzofuran-6-carboxylic acid

((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

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