DIOSMETIN

Base Information

• Chemical Name: DIOSMETIN
• CAS No.: 520-34-3
• Molecular Formula: C16H12O6
• Molecular Weight: 300.268
• Hs Code.: 29329990
• Mol file: 520-34-3.mol

Synonyms:Diosmetin(6CI);Flavone, 3',5,7-trihydroxy-4'-methoxy- (7CI,8CI);3',5,7-Trihydroxy-4'-methoxyflavone;4'-Methylluteolin;Diosmetol;Luteolin 4'-methylether;Pillon;

Chemical Property of DIOSMETIN

Chemical Property:

• Appearance/Colour: Yellow powder
• Vapor Pressure: 6.73E-14mmHg at 25°C
• Melting Point: 256-258 °C
• Refractive Index: 1.697
• Boiling Point: 576.7 °C at 760 mmHg
• PKA: 6.50±0.40(Predicted)
• Flash Point: 220.3 °C
• PSA: 100.13000
• Density: 1.512 g/cm³
• LogP: 2.58540
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO: soluble1mg/mL, clear, light yellow to yellow
• Water Solubility.: 19μg/L at 20℃

Purity/Quality:

99% ^*data from raw suppliers

Diosmetin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diosmetin (Diosmin EP Impurity F) is a metabolite of Apigenin. Antibacterial. A metabolite of Apigenin. Antibacterial

Technology Process of DIOSMETIN

There total 51 articles about DIOSMETIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

hesperetin (520-33-2,41001-90-5,69097-99-0) → diosmetin (520-34-3)

Guidance literature:

With pyridine; iodine; at 90 ℃; for 22h;

DOI:10.1002/cbic.201800431

Reference yield: 100.0%

3′,5-dihydroxy-7-(β-D-glucopyranosyloxy)-4′-methoxyflavone (20126-59-4) → diosmetin (520-34-3)

Guidance literature:

With hydrogenchloride; methanol; for 2h; Heating;

DOI:10.1248/cpb.50.788

Reference yield: 96.0%

3',5,7-triacetoxy-4'-methoxyflavone (3162-05-8) → diosmetin (520-34-3)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; ethanol; for 2h; Ambient temperature;

DOI:10.1021/jm00136a011

upstream raw materials:

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

2-(3-benzyloxy-4-methoxy-phenyl)-5,7-dihydroxy-chromen-4-one

5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-3-bromo-chroman-4-one

3′,5-dihydroxy-7-(β-D-glucopyranosyloxy)-4′-methoxyflavone

Downstream raw materials:

3',5-dihydroxy-4'-methoxy-7-(sulfopropoxy)flavone potassium salt

5-hydroxy-3',4',7-trimethoxyflavone

2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on

3,5-dihydroxyphenol

Refernces

A convenient microwave-assisted 5-amination of flavones

10.1016/j.tet.2008.09.043

This research presents an efficient method for the synthesis of 5-amino?avones, an important class of natural compounds within the ?avonoid group known for their various biological activities such as antiestrogenic, antitumor, antiallergic, and antiin?ammatory properties. The authors developed a microwave-assisted SNAr (Nucleophilic Aromatic Substitution) reaction to access 5-amino?avones, which allows for the introduction of an amino group directly onto the ?avone nucleus, a less commonly reported approach. The process involves the protection of diosmetin with benzyl bromide, followed by tri?ation and amination using various amines. The study concluded that this methodology yields good results with primary and secondary non-aromatic amines and even moderate yields with anilines, without the need for palladium catalysts or hard bases. Key chemicals used in the process include diosmetin, benzyl bromide, N-phenylbistri?imide (PhNTf2), and a range of amines such as benzylamine and its derivatives, as well as primary alkylamines and cycloalkylamines. The final step involved the removal of protective benzyl groups through catalytic hydrogenation to yield the final 5-amino?avone compounds.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 520-34-3 DIOSMETIN

Send

Send

Metric Ton KG G Pound L ML

Send

Send