3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Base Information

• Chemical Name: 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole
• CAS No.: 1449763-71-6
• Molecular Formula: C₁₄H₁₀BrN₃O₅
• Molecular Weight: 380.154
• Mol file: 1449763-71-6.mol

Synonyms:3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Chemical Property of 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

There total 4 articles about 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-bromo-N’-((5-nitrofuran-2-yl)methylene)benzohydrazide (92695-72-2) + acetic anhydride (108-24-7) → 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole (1449763-71-6)

Guidance literature:

at 110 - 120 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.03.044

Reference yield:

4-Bromobenzoic acid (586-76-5) → 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole (1449763-71-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 4 h / Reflux

2: hydrazine hydrate / water / 0.5 h / Reflux

3: sulfuric acid; acetic acid / water; methanol / 1 h / Reflux

4: 12 h / 110 - 120 °C / Inert atmosphere

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol; water;

DOI:10.1016/j.bmc.2013.06.017

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) → 3-acetyl-5-(4-bromo-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole (1449763-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / water / 0.5 h / Reflux

2: sulfuric acid; acetic acid / water; methanol / 1 h / Reflux

3: 12 h / 110 - 120 °C / Inert atmosphere

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol; water;

DOI:10.1016/j.bmc.2013.06.017

upstream raw materials:

4-Bromobenzoic acid

4-methoxycarbonylphenyl bromide

4-bromo-N’-((5-nitrofuran-2-yl)methylene)benzohydrazide

acetic anhydride