Technology Process of 4-[3-(1-cyclopentyl-4-piperidyl)indol-1-yl]aniline
There total 6 articles about 4-[3-(1-cyclopentyl-4-piperidyl)indol-1-yl]aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(1-cyclopentyl-3,6-dihydro-2H-pyridin-4-yl)-1-(4-nitrophenyl)indole;
With
hydrogen; acetic acid;
palladium 10% on activated carbon;
In
methanol;
for 18h;
under 2585.81 Torr;
With
sodium hydrogencarbonate;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium hydroxide / methanol / 18 h / 60 °C
2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: methanol; sodium tris(acetoxy)borohydride / 18 h / 20 °C
5: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 18 h / 2585.81 Torr
With
methanol; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; trifluoroacetic acid; potassium hydroxide;
palladium 10% on activated carbon;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: methanol; sodium tris(acetoxy)borohydride / 18 h / 20 °C
4: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 18 h / 2585.81 Torr
With
methanol; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; trifluoroacetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
