(αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

Base Information

Chemical Name:(αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol
CAS No.:221048-66-4
Molecular Formula:C₂₃H₂₈N₂O₃
Molecular Weight:380.487
Hs Code.:

Synonyms:(αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

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Chemical Property of (αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

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Technology Process of (αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

There total 4 articles about (αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 221048-66-4
(αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 24 h / Ambient temperature

2: NaBH₄ / methanol / 93 h

3: 98 percent / p-Tol-SO₃H / H₂O / 20 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; diethyl ether; water;
DOI:10.1016/S0040-4020(98)01117-X

Reference yield:

: 221048-53-9
(1S,2S)-(+)-2-(3-phenylprop-2-enylidene)amino-1-phenylpropane-1,3-diol

: 221048-66-4
(αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / methanol / 93 h

2: 98 percent / p-Tol-SO₃H / H₂O / 20 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; water;
DOI:10.1016/S0040-4020(98)01117-X

Reference yield:

: 221048-54-0
(1S,2S)-(+)-2-(3-phenylprop-2-enyl)amino-1-phenylpropane-1,3-diol

: 221048-66-4
(αS,1S,4S,5S,8S)-(+)-<2-tert-butyl-7-formyl-4-phenyl-3-oxa-2,7-diazabicyclo<3.3.0>oct-8-yl>-phenylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / p-Tol-SO₃H / H₂O / 20 h / Heating

With toluene-4-sulfonic acid; In water;
DOI:10.1016/S0040-4020(98)01117-X