(S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione

Base Information

• Chemical Name: (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione
• CAS No.: 141172-71-6
• Molecular Formula: C₂₁H₂₄N₂O₂
• Molecular Weight: 336.434
• Mol file: 141172-71-6.mol

Synonyms:(S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione

Chemical Property of (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione

There total 3 articles about (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-2,2-Dimethyl-3-phenyl-3-[3-((S)-1-phenyl-ethyl)-ureido]-butyric acid methyl ester (141172-70-5) → (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione (141172-71-6)

Guidance literature:

With sodium methylate; In methanol; for 8h; Heating;

DOI:10.1021/jo00038a047

Reference yield:

1-(2-Methyl-acryloyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (141172-52-3) → (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione (141172-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / benzophenone / benzene / Irradiation

2: 68 percent / NaOMe / Ambient temperature

3: 88 percent / NaOMe / methanol / 8 h / Heating

With benzophenone; sodium methylate; In methanol; benzene;

DOI:10.1021/jo00038a047

Reference yield:

(S)-2,3,3-Trimethyl-4-oxo-2-phenyl-azetidine-1-carboxylic acid ((S)-1-phenyl-ethyl)-amide (141172-59-0) → (S)-5,5,6-Trimethyl-6-phenyl-3-((S)-1-phenyl-ethyl)-dihydro-pyrimidine-2,4-dione (141172-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / NaOMe / Ambient temperature

2: 88 percent / NaOMe / methanol / 8 h / Heating

With sodium methylate; In methanol;

DOI:10.1021/jo00038a047

upstream raw materials:

(S)-2,2-Dimethyl-3-phenyl-3-[3-((S)-1-phenyl-ethyl)-ureido]-butyric acid methyl ester

1-(2-Methyl-acryloyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea

(S)-2,3,3-Trimethyl-4-oxo-2-phenyl-azetidine-1-carboxylic acid ((S)-1-phenyl-ethyl)-amide