5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

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Chemical Name:5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide
CAS No.:1448437-68-0
Molecular Formula:C₂₄H₂₈N₄O₃
Molecular Weight:420.511
Hs Code.:

Synonyms:5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

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Chemical Property of 5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

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Technology Process of 5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

There total 7 articles about 5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1448437-67-9
5-(benzylamino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

: 106-95-6
allyl bromide

: 1448437-68-0
5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: 5-(benzylamino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide; With sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 1105039-59-5
N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

: 1448437-68-0
5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / water; tetrahydrofuran / 1.67 h / -78 - -40 °C / Inert atmosphere

1.2: 2 h / -78 °C

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; palladium diacetate / 1,4-dioxane / 8 h / 110 °C / Inert atmosphere

3.1: sodium hydride / water; tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

With palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 2.1: |Buchwald-Hartwig Coupling;

Reference yield:

: 1448437-66-8
5-bromo-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

: 1448437-68-0
5-(allyl(benzyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; palladium diacetate / 1,4-dioxane / 8 h / 110 °C / Inert atmosphere

2.1: sodium hydride / water; tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

With palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 1.1: |Buchwald-Hartwig Coupling;