[N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

Base Information

Chemical Name:[N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide
CAS No.:1247018-67-2
Molecular Formula:C₂₃H₂₆F₂N₈O₂S
Molecular Weight:516.575
Hs Code.:

Synonyms:[N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

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Technology Process of [N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

There total 1 articles about [N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1247018-10-5
[N-(2-aminoethyl)-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

: 134227-45-5
3,4,5-trifluorobenzonitrile

: 1247018-67-2
[N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm1001748

Reference yield: 97.0%

: 1247018-67-2
[N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

: 90773-41-4
5-chloromethyl-1-methyl-1H-imidazole hydrochloride

: 1247018-49-0
[N-{2-[(2,6-difluoro-4-cyanophenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-ethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide

Guidance literature:: [N-{2-(2,6-difluoro-4-cyanophenyl)-aminoethyl}-N-{N-(2-pyrimidinyl)-piperidin-4-ylmethyl}]-1-methyl-1H-imidazole-4-sulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

5-chloromethyl-1-methyl-1H-imidazole hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm1001748