3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether

Base Information

• Chemical Name: 3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether
• CAS No.: 77969-37-0
• Molecular Formula: C₂₀H₂₃ClF₃NO₃
• Molecular Weight: 417.856
• Mol file: 77969-37-0.mol

Synonyms:3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether

Chemical Property of 3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether

There total 1 articles about 3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-trifluoromethyl-1-(2-bromo-1-methoxyethyl)benzene (3289-05-2) + 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine (67287-36-9) → 3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether (77969-37-0)

Guidance literature:

With potassium carbonate; In toluene; at 105 ℃; for 3h;

DOI:10.1021/jm00346a005

Reference yield:

3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether (77969-37-0) → 6-chloro-7,8-dihydroxy-1-(m-trifluoromethylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (67287-66-5)

Guidance literature:

With hydrogen bromide; at 135 ℃; for 3h;

DOI:10.1021/jm00346a005

Reference yield:

3-(trifluoromethyl)-α-<<(2-chloro-3,4-dimethoxyphenethyl)amino>methyl>benzyl methyl ether (77969-37-0) → 6-chloro-7,8-dihydroxy-3-methyl-1-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (67287-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCOOH / 5 h / Heating

2: 13 percent / 48percent aq. HBr / acetic acid / 5 h / 125 °C

With formic acid; hydrogen bromide; In acetic acid;

DOI:10.1021/jm00346a005

upstream raw materials:

3-trifluoromethyl-1-(2-bromo-1-methoxyethyl)benzene

2-(2-chloro-3,4-dimethoxyphenyl)ethylamine

Downstream raw materials:

[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethyl]-[2-methoxy-2-(3-trifluoromethyl-phenyl)-ethyl]-methyl-amine

6-chloro-7,8-dihydroxy-1-(m-trifluoromethylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

6-chloro-7,8-dihydroxy-3-methyl-1-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Refernces