5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS No.: 797053-24-8
• Molecular Formula: C₁₈H₁₃Cl₃N₂O₂
• Molecular Weight: 395.672

Synonyms:5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property of 5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

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Technology Process of 5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

There total 1 articles about 5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) + ethyl 2-chloro-α-[(dimethylamino)methylene]-β-oxo-benzenepropanoate (162509-14-0) → 5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (797053-24-8)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1016/j.bmc.2004.07.029

Reference yield: 88.0%

5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (797053-24-8) → [5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazol-4-yl]-methanol (797053-35-1)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.75h;

DOI:10.1016/j.bmc.2004.07.029

Reference yield:

5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (797053-24-8) → 5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carbaldehyde (797053-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / DIBAL-H / toluene / 0.75 h / -78 °C

2: 91 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 20 °C

With diisobutylaluminium hydride; pyridinium chlorochromate; In dichloromethane; toluene;

DOI:10.1016/j.bmc.2004.07.029

upstream raw materials:

2,4-dichlorophenyl hydrazine hydrochloride

ethyl 2-chloro-α-[(dimethylamino)methylene]-β-oxo-benzenepropanoate

Downstream raw materials:

[5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazol-4-yl]-methanol

5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-4-carbaldehyde

[5-(2-chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazol-4-yl]-phenyl-methanol

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