[2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

Base Information

Chemical Name:[2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile
CAS No.:854375-11-4
Molecular Formula:C₁₇H₁₇NO₂S
Molecular Weight:299.393
Hs Code.:

Synonyms:[2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

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Technology Process of [2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

There total 2 articles about [2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 5804-85-3
diethylaluminium cyanide

: 794525-94-3
(S)-1-[2-(p-tolylsulfinyl)phenyl]propan-2-one

: 854375-11-4
[2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

Guidance literature:: With ytterbium(III) triflate; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/j.tet.2005.10.067

Reference yield:

: 5804-85-3
diethylaluminium cyanide

: 794525-94-3
(S)-1-[2-(p-tolylsulfinyl)phenyl]propan-2-one

: 854375-11-4
[2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

: [2R,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1016/j.tet.2005.10.067

Reference yield:

: 854375-11-4
[2S,(S)S]-2-hydroxy-2-methyl-3-[2-(p-tolylsulfinyl)phenyl]propanenitrile

: (S)-2-hydroxy-2-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: fluoboric acid / CH₂Cl₂ / 6 h / -78 °C

1.2: 95 percent / NaI / CH₂Cl₂ / 15 h / 20 °C

2.1: 80 percent / Raney nickel / ethanol / 12 h / Heating

With tetrafluoroboric acid; nickel; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2005.10.067