pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

Base Information

Chemical Name:pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester
CAS No.:856241-09-3
Molecular Formula:C₂₂H₂₉N₃O₁₀
Molecular Weight:495.486
Hs Code.:

Synonyms:pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

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Chemical Property of pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

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Technology Process of pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

There total 4 articles about pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: imidazole-1-carboxylic acid 1-{4-[3-(2,2-dimethoxypropylcarbamoyl)propoxy]-5-methoxy-2-nitrophenyl}ethyl ester

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 856241-09-3
pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

Guidance literature:: imidazole-1-carboxylic acid 1-{4-[3-(2,2-dimethoxypropylcarbamoyl)propoxy]-5-methoxy-2-nitrophenyl}ethyl ester; L-proline; With 4-methyl-morpholine; In water; N,N-dimethyl-formamide; at 20 ℃; for 21.5h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1002/anie.200463065

Reference yield:

: imidazole-1-carboxylic acid 1-{4-[3-(2,2-dimethoxypropylcarbamoyl)propoxy]-5-methoxy-2-nitrophenyl}ethyl ester

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 856241-09-3
pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

: pyrrolidine-1,2-dicarboxylic acid 1-(1-{4-[3-(2,2-dimethoxypropylcarbamoyl)propoxy]-5-methoxy-2-nitrophenyl}ethyl) ester

Guidance literature:: With 4-methyl-morpholine; In water; N,N-dimethyl-formamide; at 20 ℃; for 21.5h; Title compound not separated from byproducts;
DOI:10.1002/anie.200463065

Reference yield:

: N-(2,2-dimethoxypropyl)-4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyramide

: 856241-09-3
pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / CH₂Cl₂ / 15.5 h / 20 °C

2.1: 4-methylmorpholine / dimethylformamide; H₂O / 21.5 h / 20 °C

2.2: 0.56 g / TFA / CH₂Cl₂ / 0.17 h / 20 °C

With 4-methyl-morpholine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.200463065