Tetracyclic quinolone No. 5290

Base Information

Chemical Name:Tetracyclic quinolone No. 5290
CAS No.:132305-67-0
Molecular Formula:C19H19FN4O3S
Molecular Weight:402.4426
Hs Code.:
DSSTox Substance ID:DTXSID60157488
Nikkaji Number:J445.227E
ChEMBL ID:CHEMBL88276

Synonyms:7-fluoro-9,1-((N-methylimino)methano)-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo(3,2-a)quinoline-4-carboxylic acid;7-FMMM-TQC;9,1-methyliminomethano-7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo(3,2-a)quinoline-4-carboxylic acid;tetracyclic quinolone No. 5290;TQ No. 5290

Suppliers and Price of Tetracyclic quinolone No. 5290

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 1 raw suppliers

Chemical Property of Tetracyclic quinolone No. 5290

Chemical Property:

Vapor Pressure:3.68E-17mmHg at 25°C
Boiling Point:638.2°Cat760mmHg
Flash Point:339.8°C
Density:1.62g/cm³
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:402.11618982
Heavy Atom Count:28
Complexity:794

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=C(C=C3C4=C2N(CC5=CSC(=C(C3=O)C(=O)O)N54)C)F

Technology Process of Tetracyclic quinolone No. 5290

There total 15 articles about Tetracyclic quinolone No. 5290 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 109-01-3
1-methyl-piperazine

: 132305-96-5
7,8-difluoro-9,1-<(N-methylimino)methano>-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

: 132305-67-0
9,1-methyliminomethano-7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

Guidance literature:: In dimethyl sulfoxide; at 100 ℃; for 10h;
DOI:10.1021/jm00070a005

Reference yield:

: 119474-39-4
triethylammonium N-(2,3,4-trifluorophenyl)dithiocarbamate

: 132305-67-0
9,1-methyliminomethano-7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: ethyl acetate / 0.5 h / 10 - 20 °C

2: HCl / ethyl acetate / 3.5 h / Ambient temperature

3: 89 percent / acetonitrile; H₂O / 18.5 h / Heating

4: trichloromethyl chloroformate / toluene / 17 h / 80 °C

5: Et₃N / acetonitrile / 0.67 h / Ambient temperature

6: 97 percent / fuming H₂SO₄ / 21 h / Ambient temperature

7: 56 percent / dimethylsulfoxide / 10 h / 100 °C

With hydrogenchloride; sulfuric acid; triethylamine; trichloromethyl chloroformate; In water; dimethyl sulfoxide; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 132305-92-1
4-(chloromethyl)-3-(2,3,4-trifluorophenyl)-2-(3H)-thiazolethione

: 132305-67-0
9,1-methyliminomethano-7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / acetonitrile; H₂O / 18.5 h / Heating

2: trichloromethyl chloroformate / toluene / 17 h / 80 °C

3: Et₃N / acetonitrile / 0.67 h / Ambient temperature

4: 97 percent / fuming H₂SO₄ / 21 h / Ambient temperature

5: 56 percent / dimethylsulfoxide / 10 h / 100 °C

With sulfuric acid; triethylamine; trichloromethyl chloroformate; In water; dimethyl sulfoxide; toluene; acetonitrile;