ANHYDROERYTHROMYCIN A

Base Information

• Chemical Name: ANHYDROERYTHROMYCIN A
• CAS No.: 23893-13-2
• Molecular Formula: C₃₇H₆₅NO₁₂
• Molecular Weight: 715.923
• Mol file: 23893-13-2.mol

Synonyms:6,15,16-Trioxatricyclo[10.2.1.11,4]hexadecane,erythromycin deriv.; 6,9,12-Anhydroerythromycin A; Anhydroerythromycin;Anhydroerythromycin A; BRL 46355ER; EM 202; Erythromycin anhydride

Chemical Property of ANHYDROERYTHROMYCIN A

Chemical Property:

• Vapor Pressure: 1.23E-28mmHg at 25°C
• Melting Point: 125-127°C
• Boiling Point: 787.2°Cat760mmHg
• PKA: 13.46±0.70(Predicted)
• Flash Point: 429.9°C
• PSA: 154.84000
• Density: 1.21g/cm³
• LogP: 2.98860
• Storage Temp.: −20°C
• Solubility.: Chloroform (Slightly), Methanol (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

Anhydro erythromycin A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anhydroerythromycin A is a degradation product of erythromycin formed by a complex internal rearrangement of erythromycin A on exposure to acidic conditions. In acid, erythromycin A forms the enol ether and then undergoes a second internal cyclisation of the C12–OH and C9 enol to afford the ketal, anhydroerythromycin A. Anhydroerythromycin A is an important analytical standard for erythromycin A stability studies.

Technology Process of ANHYDROERYTHROMYCIN A

There total 10 articles about ANHYDROERYTHROMYCIN A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

erythromycin A (114-07-8) → erythromycin A 6,9;9,12-spiroketal (23893-13-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 200 mg / Et₂NH, glacial CH₃COOH / acetonitrile / 72 h / 45 - 50 °C

2: 100 percent / CH₃COOH / 4 h / Ambient temperature

3: pyridine, acetic acid / 24 h / 70 °C

4: 340 mg / 10percent aq. HCl / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; acetic acid; diethylamine; In acetonitrile;

DOI:10.1021/jo00382a004

Reference yield:

erythromycin (114-07-8) → anhydroerythromycin (23893-13-2)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01579a060

Reference yield:

9-deoxo-9-iminoerythromycin A (30760-16-8) → anhydroerythromycin A (23893-13-2)

Guidance literature:

With water; In methanol; at 23 ℃; pH 1.5;

upstream raw materials:

erythromycin

9-deoxo-9-iminoerythromycin A

erythromycin A

erythromycin A enol ether