{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

Base Information

Chemical Name:{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid
CAS No.:252353-72-3
Molecular Formula:C₂₄H₃₉N₃O₆
Molecular Weight:465.59
Hs Code.:

{4-[benzyl-(3-<i>tert</i>-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

Synonyms:{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

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Chemical Property of {4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

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Technology Process of {4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

There total 11 articles about {4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252353-66-5
{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid methyl ester

: 252353-72-3
{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

Guidance literature:: With sodium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 15h;
DOI:10.1021/jm991043x

Reference yield:

: 1629-58-9
4-penten-3-one

: 252353-72-3
{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: methanol / 2 h / 40 °C

2: NaBH₄ / ethanol / 3 h / 10 °C

3: H₂ / 10 percent Pd/C / methanol / 6 h / 20 °C / 760 Torr

4: KI; Na₂CO₃ / butan-1-ol / 2 h / Heating

5: Et₃N / CH₂Cl₂ / 1 h

6: NaN₃ / dimethylsulfoxide / 15 h / 40 - 45 °C

7: H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 20 °C / 3000.24 Torr

8: H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

9: Et₃N / toluene / 15 h / 80 °C

10: 1N NaOH / 1,2-dimethoxy-ethane / 15 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; sodium azide; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; nickel; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; butan-1-ol; 1: Addition / 2: Reduction / 3: Hydrogenolysis / 4: Alkylation / 5: Mesylation / 6: Substitution / 7: Reduction-tert-butyloxycarbonylation / 8: Catalytic hydrogenation / 9: Condensation / 10: Hydrolysis;
DOI:10.1021/jm991043x

Reference yield:

: 252353-57-4
1-benzylamino-pentan-3-ol

: 252353-72-3
{4-[benzyl-(3-tert-butoxycarbonylamino-pentyl)-amino]-butylcarbamoyloxy}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: KI; Na₂CO₃ / butan-1-ol / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h

3: NaN₃ / dimethylsulfoxide / 15 h / 40 - 45 °C

4: H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 20 °C / 3000.24 Torr

5: H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

6: Et₃N / toluene / 15 h / 80 °C

7: 1N NaOH / 1,2-dimethoxy-ethane / 15 h / 20 °C

With sodium hydroxide; sodium azide; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; nickel; In 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; butan-1-ol; 1: Alkylation / 2: Mesylation / 3: Substitution / 4: Reduction-tert-butyloxycarbonylation / 5: Catalytic hydrogenation / 6: Condensation / 7: Hydrolysis;
DOI:10.1021/jm991043x