5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine

Base Information

• Chemical Name: 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine
• CAS No.: 59469-06-6
• Molecular Formula: C₂₀H₁₇ClFN₃O
• Molecular Weight: 369.826
• Mol file: 59469-06-6.mol

Synonyms:5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine

Chemical Property of 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine

There total 11 articles about 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-chloro-6-(2-fluorophenyl)-5,6-dihydro-1-methyl-6H-imidazo<1,5-a><1,4>benzodiazepine (59468-07-4) → 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine (59469-06-6)

Guidance literature:

With pyridine; acetic anhydride; In dichloromethane; Petroleum ether;

Reference yield:

7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2-(1-nitromethylene)-2H-1,4-benzodiazepine 4-oxide → 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine (59469-06-6)

Guidance literature:

Multi-step reaction with 6 steps

1: aluminum nickel / tetrahydrofuran; methanol

2: PPA; acetic anhydride / methanol; dichloromethane; water

3: hydrogen / dichloromethane; water; acetic acid; Petroleum ether

4: manganese dioxide / toluene

5: zinc / dichloromethane; water; acetic acid

6: pyridine; acetic anhydride / dichloromethane; Petroleum ether

With pyridine; PPA; manganese dioxide; hydrogen; acetic anhydride; zinc; aluminum nickel; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; toluene; Petroleum ether;

Reference yield:

8-chloro-6-(2-fluorophenyl)-1-hydroxy-methyl-4H-imidazo(1,5-a)(1,4)-benzodiazepine (59469-03-3) → 5-acetyl-8-chloro-6-(2-fluoro-phenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine (59469-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; sodium methylate; acetic anhydride / methanol

2: zinc / dichloromethane; water; acetic acid

3: pyridine; acetic anhydride / dichloromethane; Petroleum ether

With pyridine; sodium methylate; acetic anhydride; zinc; In methanol; dichloromethane; water; acetic acid; Petroleum ether;

upstream raw materials:

8-chloro-6-(2-fluorophenyl)-5,6-dihydro-1-methyl-6H-imidazo<1,5-a><1,4>benzodiazepine

8-chloro-6-(2-fluorophenyl)-1-hydroxy-methyl-4H-imidazo(1,5-a)(1,4)-benzodiazepine

8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo<1,5-a><1,4>benzodiazepine

Midazolam