benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

Base Information

Chemical Name:benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate
CAS No.:1043504-47-7
Molecular Formula:C₃₀H₃₆NO₇P
Molecular Weight:553.592
Hs Code.:

Synonyms:benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

Chemical Property:

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Technology Process of benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

There total 8 articles about benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 56777-24-3
benzyl (S)-Lactate

: 106019-45-8
benzyl hydrogen [(R,S)-1-(benzyloxycarbonylamino)pent-1-yl]phosphonate

: 1043504-47-7
benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

Guidance literature:: With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetlet.2008.05.028

Reference yield:

: 80088-88-6
[(R,S)-1-(benzyloxycarbonylamino)pentyl]phosphonic acid

: 1043504-47-7
benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; benzene / 12 h / 80 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 12 h / 80 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/j.tet.2009.05.051

Reference yield:

: 1043504-42-2
dibenzyl [(R,S)-1-(benzyloxycarbonylamino)pentyl]phosphonate

: 1043504-47-7
benzyl (2S)-2-{[(R,S)-1-benzyloxycarbonylaminopentyl(benzyloxy)phosphoryl]oxy}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 12 h / 80 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2009.05.051