(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

Base Information

Chemical Name:(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol
CAS No.:129365-60-2
Molecular Formula:C₁₆H₂₁FO₅
Molecular Weight:312.338
Hs Code.:

Synonyms:(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

There total 3 articles about (3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 129365-59-9
(3aS,4S,4aR,7aS,8S,8aS)-4-Benzyloxy-8-fluoro-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxole

: 129365-60-2
(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

Guidance literature:: With hydrogenchloride; In dichloromethane; at 23 ℃; for 0.666667h;
DOI:10.1021/ja00176a055

Reference yield:

: 129444-05-9
(3aS,4S,4aR,7aS,8S,8aS)-8-Fluoro-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

: 129365-60-2
(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaH / dimethylformamide / 0 °C

2: 80 percent / acetyl chloride / CH₂Cl₂; methanol / 0.17 h / Ambient temperature

With sodium hydride; acetyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00169-4

Reference yield:

: 120444-24-8
D-3-deoxy-3-fluoro-myo-inositol

: 129365-60-2
(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

Guidance literature:: Multi-step reaction with 3 steps

1: CSA / dimethylformamide / 5 h / 65 °C

2: 95 percent / NaH / dimethylformamide / 0 °C

3: 80 percent / acetyl chloride / CH₂Cl₂; methanol / 0.17 h / Ambient temperature

With camphor-10-sulfonic acid; sodium hydride; acetyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00169-4