(1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate

Base Information

• Chemical Name: (1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate
• CAS No.: 259823-95-5
• Molecular Formula: C₁₂H₂₂O₃
• Molecular Weight: 214.305
• Mol file: 259823-95-5.mol

Synonyms:(1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate

Chemical Property of (1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate

Chemical Property:

Purity/Quality:

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Technology Process of (1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate

There total 1 articles about (1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

romandolide (236391-76-7) → (1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate (259823-95-5)

Guidance literature:

With sodium methylate; In methanol; at -78 - -50 ℃; for 1.5h;

Reference yield: 93.0%

(1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate (259823-95-5) + <3,3,3-2H3>propionic acid (55577-88-3) → (+)-2-{(1S)-1-[(1R)-3,3-dimethylcyclohexyl]ethoxy}-2-oxoethyl (3,3,3-(2)H3)propanoate (1197240-87-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 24h;

DOI:10.1002/hlca.200900076

Reference yield: 92.0%

monomethyl oxalyl chloride (5781-53-3) + (1S,1'R)-1-(3',3'-dimethyl-1'-cyclohexyl)ethyl hydroxyacetate (259823-95-5) → (1S,1R')-1-[(3',3'-dimethyl-1'-cyclohexyl)ethoxycarbonyl]methyl methyl oxalate

Guidance literature:

With pyridine; In diethyl ether; at 30 ℃; for 0.5h;

upstream raw materials:

romandolide

Downstream raw materials:

(+)-2-{(1S)-1-[(1R)-3,3-dimethylcyclohexyl]ethoxy}-2-oxoethyl (3,3,3-⁽²⁾H₃)propanoate