3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Base Information

Chemical Name:3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide
CAS No.:79106-72-2
Molecular Formula:C₂₅H₃₁N₅O₃
Molecular Weight:449.553
Hs Code.:

Synonyms:3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

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Chemical Property of 3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

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Technology Process of 3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

There total 8 articles about 3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 79106-66-4
3-{1-[2-(3,4-Dimethoxy-phenyl)-1-methyl-2-oxo-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

: 79106-72-2
3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 1.5h; Ambient temperature;
DOI:10.1002/jhet.5570200315

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 79106-72-2
3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2) NaBH₄ / 1) methanol, 20 deg C, 1 h; 2) 1 h

2: 78 percent / H₂ / Pd/C / ethanol / 10 h / 20 °C / 2585.7 Torr

3: 43 percent / DBU / dioxane / 10 h / 20 °C

4: 94 percent / HCl / ethyl acetate / Ambient temperature

5: 55 percent / triethylamine / methanol / 20 °C

6: 85 percent / NaBH₄ / ethanol / 1.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; ethyl acetate;
DOI:10.1002/jhet.5570200315

Reference yield:

: 87120-79-4
tert-butyl 4-((2-nitrobenzyl)amino)piperidine-1-carboxylate

: 79106-72-2
3-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / H₂ / Pd/C / ethanol / 10 h / 20 °C / 2585.7 Torr

2: 43 percent / DBU / dioxane / 10 h / 20 °C

3: 94 percent / HCl / ethyl acetate / Ambient temperature

4: 55 percent / triethylamine / methanol / 20 °C

5: 85 percent / NaBH₄ / ethanol / 1.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; ethyl acetate;
DOI:10.1002/jhet.5570200315