Araprofen

Base Information

• Chemical Name: Araprofen
• CAS No.: 15250-13-2
• Molecular Formula: C₁₆H₁₅NO₄
• Molecular Weight: 285.299
• Hs Code.: 2922499990
• Mol file: 15250-13-2.mol

Synonyms:Hydratropicacid, p-(o-carboxyanilino)- (8CI); Araprofen

Chemical Property of Araprofen

Chemical Property:

• Vapor Pressure: 1.11E-10mmHg at 25°C
• Melting Point: 191-192 °C(Solv: acetonitrile (75-05-8))
• Boiling Point: 496.6°Cat760mmHg
• PKA: 3.69±0.36(Predicted)
• Flash Point: 254.2°C
• PSA: 86.63000
• Density: 1.341g/cm³
• LogP: 3.38950

Purity/Quality:

99% ^*data from raw suppliers

ARAPROFEN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Therapeutic Function: Antiinflammatory, Analgesic

Technology Process of Araprofen

There total 4 articles about Araprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(1-Methoxycarbonyl-ethyl)-phenylamino]-benzoic acid → (+/-)-2-propionic acid (15250-13-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Yield given; Heating;

DOI:10.1002/jps.2600790219

Reference yield:

methyl 2-(4-aminophenyl)propanoate (39718-97-3) → (+/-)-2-propionic acid (15250-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, Cu / dimethylformamide / 3.5 h / 140 - 145 °C

2: aq. NaOH / ethanol / 0.5 h / Heating

With sodium hydroxide; copper; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jps.2600790219

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → (+/-)-2-propionic acid (15250-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, Cu / dimethylformamide / 3.5 h / 140 - 145 °C

2: aq. NaOH / ethanol / 0.5 h / Heating

With sodium hydroxide; copper; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jps.2600790219

upstream raw materials:

methyl 2-(4-aminophenyl)propanoate

ortho-chlorobenzoic acid

Refernces