(4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

Base Information

Chemical Name:(4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane
CAS No.:426841-74-9
Molecular Formula:C₂₀H₂₅N₃O₄
Molecular Weight:371.436
Hs Code.:

Synonyms:(4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

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Chemical Property of (4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

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Technology Process of (4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

There total 1 articles about (4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 426841-73-8
(4S,6R)-4-[(1E)-3-acetyloxypenta-1,4-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

: 426841-74-9
(4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

Guidance literature:: With sodium azide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; for 1h; Heating;
DOI:10.1055/s-2002-20037

Reference yield:

: 426841-74-9
(4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

: [(4R,6S)-6-((1E,3E)-5-Azido-penta-1,3-dienyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid

Guidance literature:: With sodium hydroxide; In methanol; at 23 ℃; for 12h;
DOI:10.1055/s-2002-20037

Reference yield:

: 426841-74-9
(4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-isopropoxycarbonylmethyl-2-phenyl-1,3-dioxane

: (4S,6R)-4-[(1E,3E)-5-azidopenta-1,3-dienyl]-6-[(4-(methoxycarbonyl)-2-oxazolyl)methyl]-2-phenyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 12 h / 23 °C

2: 17 mg / N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 15 h / -30 - 23 °C

3: Burgess' reagent / tetrahydrofuran / 2 h / 60 °C

4: 3.4 mg / BrCCl₃; DBU / CH₂Cl₂ / 15 h / 23 °C

With 4-methyl-morpholine; sodium hydroxide; Burgess Reagent; Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2002-20037