methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Base Information

Chemical Name:methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate
CAS No.:1260171-71-8
Molecular Formula:C₂₉H₃₈N₄O₇S₂
Molecular Weight:618.775
Hs Code.:

Synonyms:methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

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Chemical Property of methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

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Technology Process of methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

There total 5 articles about methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 477585-31-2
4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride salt

: methyl (S)-3-amino-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]propanoate dihydrochloride

: 1260171-71-8
methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 64.0%

: 1260171-71-8
methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Guidance literature:

Reference yield:

: 4-chloromethyl-2-methylquinoline hydrochloride salt

: 1260171-71-8
methyl (S)-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; isopropyl alcohol / 23 h / 40 - 70 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 18 h / -10 - 20 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

With oxalyl dichloride; triethylamine; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;