1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Base Information

Chemical Name:1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester
CAS No.:151978-61-9
Molecular Formula:C₂₄H₂₁N₃O₄
Molecular Weight:415.448
Hs Code.:

Synonyms:1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

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Chemical Property of 1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

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Technology Process of 1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

There total 7 articles about 1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119-68-6
N-Methylanthranilic acid

: 151978-61-9
1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ICl

2: K₂CO₃

3: Et₃N, DMAP / dimethylformamide

4: CH₂Cl₂; H₂O

5: CsCO₃ / dimethylformamide

6: Pd(Ph₃P)2Cl₂, CuI, Et₃N / ethyl acetate

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; potassium carbonate; triethylamine; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00091a008

Reference yield:

: 151979-21-4
5-Iodo-2-methylamino-benzoic acid

: 151978-61-9
1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃

2: Et₃N, DMAP / dimethylformamide

3: CH₂Cl₂; H₂O

4: CsCO₃ / dimethylformamide

5: Pd(Ph₃P)2Cl₂, CuI, Et₃N / ethyl acetate

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00091a008

Reference yield:

: 151979-22-5
5-iodo-N-methylisatoic anhydride

: 151978-61-9
1-(methyl)-4-(2-carboxyethyl)-7-(4-cyanophenyl)ethynyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, DMAP / dimethylformamide

2: CH₂Cl₂; H₂O

3: CsCO₃ / dimethylformamide

4: Pd(Ph₃P)2Cl₂, CuI, Et₃N / ethyl acetate

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00091a008