5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

Base Information

• Chemical Name: 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile
• CAS No.: 103524-84-1
• Molecular Formula: C₂₆H₃₇N₃O₄
• Molecular Weight: 455.597

Synonyms:5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

Chemical Property of 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

Chemical Property:

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Technology Process of 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

There total 3 articles about 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Isopropyl-5-[3-(3-nitro-phenoxy)-propylamino]-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile (103524-86-3) → 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile (103524-84-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; Ambient temperature;

DOI:10.1248/cpb.36.373

Reference yield:

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile (66332-86-3) → 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile (103524-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) EtOH, 1.5 h, reflux, 2.) EtOH, ice water, 1 h, room temp.

2: 99 percent / hydrogen / PtO₂ / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1248/cpb.36.373

Reference yield:

3-(3-nitrophenoxy)-1-aminopropane (116753-51-6) → 5-[3-(3-Amino-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile (103524-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) EtOH, 1.5 h, reflux, 2.) EtOH, ice water, 1 h, room temp.

2: 99 percent / hydrogen / PtO₂ / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1248/cpb.36.373

upstream raw materials:

2-Isopropyl-5-[3-(3-nitro-phenoxy)-propylamino]-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile

3-(3-nitrophenoxy)-1-aminopropane

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