(E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

Base Information

Chemical Name:(E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide
CAS No.:948910-30-3
Molecular Formula:C₂₀H₁₉ClN₂O₅S
Molecular Weight:434.9
Hs Code.:

Synonyms:(E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

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Chemical Property of (E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

Chemical Property:

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Technology Process of (E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

There total 4 articles about (E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 948910-14-3
N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)(cyanomethane)sulfonamide

: 122-51-0
orthoformic acid triethyl ester

: 948910-30-3
(E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

Guidance literature:: In acetic anhydride; for 2h; Heating;
DOI:10.1007/s00706-006-0536-7

Reference yield:

: 948910-01-8
N-(2-chlorobenzyl)(cyanomethane)sulfonamide

: 948910-30-3
(E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 0.17 h / -78 °C

1.2: 66 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 74 percent / acetic anhydride / 2 h / Heating

With n-butyllithium; In tetrahydrofuran; acetic anhydride;
DOI:10.1007/s00706-006-0536-7

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 948910-30-3
(E)-N-(benzyloxycarbonyl)-N-(2-chlorobenzyl)-1-cyano-2-ethoxyethene-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 0.17 h / -78 °C

1.2: 66 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 74 percent / acetic anhydride / 2 h / Heating

With n-butyllithium; In tetrahydrofuran; acetic anhydride;
DOI:10.1007/s00706-006-0536-7