4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

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Chemical Name:4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid
CAS No.:1266160-38-6
Molecular Formula:C₂₅H₁₇FN₄O₃
Molecular Weight:440.433
Hs Code.:

Synonyms:4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

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Chemical Property of 4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

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Technology Process of 4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

There total 5 articles about 4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120153-08-4
4-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1266162-05-3
6-chloro-4-hydrazinyl-2-(4-phenoxyphenyl)nicotinonitrile

: 1266160-38-6
4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 85 ℃; for 21.5h; Inert atmosphere; Sealed tube;

Reference yield:

: 3096-81-9
4-phenoxybenzonitrile

: 1266160-38-6
4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2: 0.17 h / 250 °C / Microwave irradiation

3: trichlorophosphate / 2 h / 90 °C / Sonographic reaction

4: hydrazine / dichloromethane / 72 h / 20 °C

5: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 21.5 h / 85 °C / Inert atmosphere; Sealed tube

With potassium phosphate; n-butyllithium; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 5: Suzuki Coupling;

Reference yield:

: 1266161-61-8
3-amino-3-(4-phenoxyphenyl)acrylonitrile

: 1266160-38-6
4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 0.17 h / 250 °C / Microwave irradiation

2: trichlorophosphate / 2 h / 90 °C / Sonographic reaction

3: hydrazine / dichloromethane / 72 h / 20 °C

4: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 21.5 h / 85 °C / Inert atmosphere; Sealed tube

With potassium phosphate; hydrazine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; 4: Suzuki Coupling;