Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C
1.2: 3 h
2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 2 h / -70 °C
2.2: -70 - 20 °C
3.1: sodium hydroxide / ethanol / 1.5 h / 120 °C / Sealed; Microwave irradiation
3.2: pH 6 / Cooling with ice
4.1: dmap / dichloromethane / 20 °C
5.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 0.75 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation
6.1: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 1.5 h / 180 °C / Inert atmosphere; Sealed; Microwave irradiation
7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation
8.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Microwave irradiation
With
dmap; potassium phosphate; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; potassium acetate; sodium hydride; sodium hydroxide; tricyclohexylphosphine;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;