N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

Base Information

Chemical Name:N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide
CAS No.:1368807-00-4
Molecular Formula:C₃₉H₃₈N₂O₂S
Molecular Weight:598.809
Hs Code.:

Synonyms:N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

Suppliers and Price of N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

Chemical Property:

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Technology Process of N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

There total 6 articles about N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1368806-99-8
C₂HF₃O₂*C₁₇H₂₀N₂O

: 75286-49-6,75368-95-5
S-trityl-2-mercaptopropionic acid

: 1368807-00-4
N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/cmdc.201100522

Reference yield:

: 4-phenylbut-3-yn-2-one O-methyl oxime

: 1368807-00-4
N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: Iodine monochloride / dichloromethane / 20 °C

2: copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 130 °C / Microwave irradiation

3: dichloromethane / 4 h / 20 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; Iodine monochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1002/cmdc.201100522

Reference yield:

: 16114-53-7
4-iodo-3-methyl-5-phenylisoxazole

: 1368807-00-4
N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 130 °C / Microwave irradiation

2: dichloromethane / 4 h / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1002/cmdc.201100522