1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

Base Information

Chemical Name:1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea
CAS No.:1429501-79-0
Molecular Formula:C₂₉H₂₆Cl₂N₆O₃
Molecular Weight:577.47
Hs Code.:

Synonyms:1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

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Chemical Property of 1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

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Technology Process of 1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

There total 5 articles about 1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1338681-43-8
[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid

: 1429500-49-1
{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}carbamic azide

: 1429501-79-0
1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

Guidance literature:: With sodium azide; diphenyl phosphoryl azide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 1429500-38-8
ethyl [7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate

: 1429500-49-1
{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}carbamic azide

: 1429501-79-0
1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 18 h / 20 °C

2: sodium azide; diphenyl phosphoryl azide / tetrahydrofuran / 18 h / 20 °C

With sodium azide; diphenyl phosphoryl azide; water; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1429500-49-1
{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}carbamic azide

: 1429501-79-0
1,3-bis{[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]methyl}urea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 18 h / 20 °C

3: sodium azide; diphenyl phosphoryl azide / tetrahydrofuran / 18 h / 20 °C

With sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diphenyl phosphoryl azide; water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;