Technology Process of (2R,3S)-2-Benzyloxy-3-fluoro-3-(2-methyl-[1,3]dioxan-2-yl)-propan-1-ol
There total 12 articles about (2R,3S)-2-Benzyloxy-3-fluoro-3-(2-methyl-[1,3]dioxan-2-yl)-propan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
at 20 ℃;
for 4h;
DOI:10.1021/ol048459b
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 78 percent / pyridine / 20 °C
2: 65 percent / trifluoromethanesulfonic acid / cyclohexane; CH2Cl2 / 20 °C
3: 66 percent / sodium methoxide / methanol / 3 h / 20 °C
4: pyridine / CH2Cl2 / 0.5 h
5: 998 mg / sodium borohydride / acetonitrile / 20 °C
6: 74 percent / hydrochloric acid / dioxane / 5 h / Heating
7: 64 percent / NaBH4 / methanol / 2 h / 20 °C
8: 80 percent / pyridine / 20 °C
9: 77 percent / oxalyl chloride; dimethyl sulfoxide; diisopropylethylamine / CH2Cl2 / 0.17 h
10: 84 percent / p-toluenesulfonic acid monohydrate / benzene / Heating
11: 77 percent / sodium methoxide / methanol / 4 h / 20 °C
With
pyridine; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; trifluorormethanesulfonic acid; sodium methylate; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; dichloromethane; cyclohexane; acetonitrile; benzene;
9: Swern oxidation;
DOI:10.1021/ol048459b
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 65 percent / trifluoromethanesulfonic acid / cyclohexane; CH2Cl2 / 20 °C
2: 66 percent / sodium methoxide / methanol / 3 h / 20 °C
3: pyridine / CH2Cl2 / 0.5 h
4: 998 mg / sodium borohydride / acetonitrile / 20 °C
5: 74 percent / hydrochloric acid / dioxane / 5 h / Heating
6: 64 percent / NaBH4 / methanol / 2 h / 20 °C
7: 80 percent / pyridine / 20 °C
8: 77 percent / oxalyl chloride; dimethyl sulfoxide; diisopropylethylamine / CH2Cl2 / 0.17 h
9: 84 percent / p-toluenesulfonic acid monohydrate / benzene / Heating
10: 77 percent / sodium methoxide / methanol / 4 h / 20 °C
With
pyridine; hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; trifluorormethanesulfonic acid; sodium methylate; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; dichloromethane; cyclohexane; acetonitrile; benzene;
8: Swern oxidation;
DOI:10.1021/ol048459b
![Benzoic acid (2R,3S)-2-benzyloxy-3-fluoro-3-(2-methyl-[1,3]dioxan-2-yl)-propyl ester](/Databaselist/images/loading.webp)
