4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

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Chemical Name:4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile
CAS No.:1456892-90-2
Molecular Formula:C₂₁H₁₈BrF₃N₄O
Molecular Weight:479.299
Hs Code.:

Synonyms:4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

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Chemical Property of 4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

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Technology Process of 4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

There total 12 articles about 4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845616-12-8
2-bromo-5-cyanobenzoic acid

: 1456892-82-2
C₁₃H₁₆F₃N₃

: 1456892-90-2
4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

Guidance literature:: 2-bromo-5-cyanobenzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 1,4-dioxane; at 25 ℃; for 0.5h;

C₁₃H₁₆F₃N₃; In 1,4-dioxane; at 60 ℃; for 1h;

Reference yield:

: 2840-02-0
5-acetamido-2-bromobenzoic acid

: 1456892-90-2
4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.58 h / 0 °C

1.2: 0.25 h / 60 °C

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

2.2: 1 h / 60 °C

With 4-methyl-morpholine; hydrogenchloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium nitrite; In 1,4-dioxane; water;

Reference yield:

: (3S)-tert-butyl 3-((1,3-dioxoisoindolin-2-yl)methyl)-2-azabicyclo[4.1.0]-heptane-2-carboxylate

: 1456892-90-2
4-bromo-3-((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 16 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

4.2: 1 h / 60 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrazine hydrate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;