Technology Process of 2-benzyloxy-3,9,10-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
There total 8 articles about 2-benzyloxy-3,9,10-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / methanol / 6 h / 0 °C
2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux
With
sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
2: |Williamson Ether Synthesis;
DOI:10.1016/j.tet.2015.01.004
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C
1.2: 1 h / 0 - 20 °C
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 0.75 h / -78 °C
3.1: potassium carbonate; water / methanol / 1 h / Reflux
4.1: tetrahydrofuran / 1 h / 0 - 20 °C
5.1: tetrahydrofuran / 0 - 20 °C
6.1: trichlorophosphate / acetonitrile / 3 h / Reflux
7.1: sodium tetrahydroborate / methanol / 6 h / 0 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C
9.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; water; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
6.1: |Bischler-Napieralski Reaction / 8.1: |Williamson Ether Synthesis;
DOI:10.1016/j.tet.2015.01.004
