1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea

Base Information

• Chemical Name: 1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea
• CAS No.: 1625672-08-3
• Molecular Formula: C₂₄H₂₂F₃N₃O₃
• Molecular Weight: 457.452

Synonyms:1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea

Chemical Property of 1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea

Chemical Property:

Purity/Quality:

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Technology Process of 1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea

There total 2 articles about 1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-((4-cyanophenyl)(2-hydroxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea (1625672-07-2) + triethyloxonium fluoroborate (368-39-8) → 1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea (1625672-08-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

N-(3-trifluoromethylphenyl)urea (13114-87-9) → 1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea (1625672-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide; acetonitrile / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

1-((4-cyanophenyl)(2-ethoxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea (1625672-08-3) → 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile (1625675-73-1)

Guidance literature:

With sodium t-butanolate; In acetonitrile; for 0.333333h;

upstream raw materials:

1-((4-cyanophenyl)(2-hydroxy-6-oxocyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)-phenyl)urea

triethyloxonium fluoroborate

N-(3-trifluoromethylphenyl)urea

Downstream raw materials:

4-nitrophenyl 4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxylate

4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile

methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)propanoate

2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)propanoic acid

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