Technology Process of (2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide
There total 6 articles about (2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
In
tetrahydrofuran;
at -60 ℃;
DOI:10.1248/cpb.37.3161
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / H2, NEt3 / 2, (4S,5S)-MOD-DIOP (12) / methanol / 40 h / 30 °C / 760 Torr
2: 1) aq. KOH, 2) CaCl2, NaBH4, KOH / 1) methanol, ice bath, 15 min, 2) ethanol, room temperature, 3 h
3: HCl / ethanol / 0.5 h
4: 1) lithium diisopropylamide, HMPA / 1) THF, hexane, -60 deg C, 30 min, 2) -60 deg C, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triethylamine; calcium chloride; lithium diisopropyl amide;
chloro(1,5-cyclooctadiene)rhodium(I) dimer; (4S,5S)-MOD-DIOP (12);
In
methanol; ethanol;
DOI:10.1016/S0040-4020(01)80536-6
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium methoxide
2: 80 percent / H2, NEt3 / 2, (4S,5S)-MOD-DIOP (12) / methanol / 40 h / 30 °C / 760 Torr
3: 1) aq. KOH, 2) CaCl2, NaBH4, KOH / 1) methanol, ice bath, 15 min, 2) ethanol, room temperature, 3 h
4: HCl / ethanol / 0.5 h
5: 1) lithium diisopropylamide, HMPA / 1) THF, hexane, -60 deg C, 30 min, 2) -60 deg C, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium methylate; triethylamine; calcium chloride; lithium diisopropyl amide;
chloro(1,5-cyclooctadiene)rhodium(I) dimer; (4S,5S)-MOD-DIOP (12);
In
methanol; ethanol;
DOI:10.1016/S0040-4020(01)80536-6