(2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Base Information

Chemical Name:(2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide
CAS No.:127767-58-2
Molecular Formula:C₂₁H₂₀O₇
Molecular Weight:384.386
Hs Code.:

Synonyms:(2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Suppliers and Price of (2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

There total 6 articles about (2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 108102-77-8
(R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one

: 127767-57-1
ethyl carbonic-piperonylic anhydride

: 127767-58-2
(2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -60 ℃;
DOI:10.1248/cpb.37.3161

Reference yield:

: 115061-18-2
(E)-3-(methoxycarbonyl)-4-(3,4-dimethoxyphe-nyl)but-3-enoic acid

: 127767-58-2
(2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / H₂, NEt₃ / 2, (4S,5S)-MOD-DIOP ⁽¹²⁾ / methanol / 40 h / 30 °C / 760 Torr

2: 1) aq. KOH, 2) CaCl₂, NaBH₄, KOH / 1) methanol, ice bath, 15 min, 2) ethanol, room temperature, 3 h

3: HCl / ethanol / 0.5 h

4: 1) lithium diisopropylamide, HMPA / 1) THF, hexane, -60 deg C, 30 min, 2) -60 deg C, 1 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triethylamine; calcium chloride; lithium diisopropyl amide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (4S,5S)-MOD-DIOP ⁽¹²⁾; In methanol; ethanol;
DOI:10.1016/S0040-4020(01)80536-6

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 127767-58-2
(2R,3R)-3-(3',4'-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzoyl)-4-butanolide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methoxide

2: 80 percent / H₂, NEt₃ / 2, (4S,5S)-MOD-DIOP ⁽¹²⁾ / methanol / 40 h / 30 °C / 760 Torr

3: 1) aq. KOH, 2) CaCl₂, NaBH₄, KOH / 1) methanol, ice bath, 15 min, 2) ethanol, room temperature, 3 h

4: HCl / ethanol / 0.5 h

5: 1) lithium diisopropylamide, HMPA / 1) THF, hexane, -60 deg C, 30 min, 2) -60 deg C, 1 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium methylate; triethylamine; calcium chloride; lithium diisopropyl amide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (4S,5S)-MOD-DIOP ⁽¹²⁾; In methanol; ethanol;
DOI:10.1016/S0040-4020(01)80536-6