(R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Base Information

Chemical Name:(R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol
CAS No.:1404458-83-8
Molecular Formula:C₃₀H₄₂O₂Si
Molecular Weight:462.748
Hs Code.:

Synonyms:(R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Suppliers and Price of (R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

There total 7 articles about (R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404458-69-0
(E)-tert-butyl((5-iodo-3-methylhexa-2,5-diendien-1-yl)oxy)diphenylsilane

: 2043-61-0
cyclohexanecarbaldehyde

: 1404458-83-8
(R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

: (S,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Guidance literature:: With chromium dichloride; manganese; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₁₀H₁₀O₄*NiCl₂; lithium chloride; In acetonitrile; at 20 ℃; for 3h; Overall yield = 54 %; Overall yield = 170 mg; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302751b

Reference yield:

: 1404458-81-6
(E)-tert-butyl((3-methylhex-2-en-5-yn-1-yl)oxy)diphenylsilane

: 1404458-83-8
(R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

: (S,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -40 °C / Inert atmosphere

1.2: 2.5 h / -78 °C / Inert atmosphere

2.1: N-iodo-succinimide / dichloromethane / 0.17 h / 0 °C

3.1: N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; chromium dichloride; lithium chloride; manganese; C₁₀H₁₀O₄*NiCl₂; zirconocene dichloride / acetonitrile / 3 h / 20 °C / Inert atmosphere

With chromium dichloride; manganese; N-iodo-succinimide; n-butyllithium; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₁₀H₁₀O₄*NiCl₂; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 3.1: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1021/ol302751b

Reference yield:

: (E)-tert-butyl((5-iodo-3-methylhexa-2,5-diendien-1-yl)oxy)diphenylsilane

: 1404458-83-8
(R,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

: (S,E)-6-(tert-butyldiphenylsilyloxy)-1-cyclohexyl-4-methyl-2-methylenehex-4-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / dichloromethane / 0.17 h / 0 °C

2: N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; chromium dichloride; lithium chloride; manganese; C₁₀H₁₀O₄*NiCl₂; zirconocene dichloride / acetonitrile / 3 h / 20 °C / Inert atmosphere

With chromium dichloride; manganese; N-iodo-succinimide; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₁₀H₁₀O₄*NiCl₂; lithium chloride; In dichloromethane; acetonitrile; 2: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1021/ol302751b