(-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine

Base Information

• Chemical Name: (-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine
• CAS No.: 1380414-69-6
• Molecular Formula: C₂₀H₂₉NO₂S
• Molecular Weight: 347.522

Synonyms:(-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine

Chemical Property of (-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine

Chemical Property:

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Technology Process of (-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine

There total 2 articles about (-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C20H29NS → (-)-(5R,8aS)-5-hexyl-7-(phenylsulfinyl)-1,2,3,5,8,8a-hexahydroindolizine (1380414-65-2) + (+)-(5S,8aR)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine (1380414-60-7) + (-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine (1380414-69-6)

Guidance literature:

C₂₀H₂₉NS; With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 0.166667h; Molecular sieve;

With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; In toluene; at 20 ℃; for 0.166667h;

With tert.-butylhydroperoxide; In toluene; at 0 ℃; for 18h; optical yield given as %ee;

DOI:10.1016/j.tet.2012.04.054

Reference yield: 27.0%

C20H29NS → (+)-(5S,8aR)-5-hexyl-7-(phenylsulfinyl)-1,2,3,5,8,8a-hexahydroindolizine (1380414-68-5) + (-)-(5R,8aS)-5-hexyl-7-(phenylsulfonyl)-1,2,3,5,8,8a-hexahydroindolizine (1380414-69-6)

Guidance literature:

C₂₀H₂₉NS; With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 0.166667h; Molecular sieve;

With titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; In toluene; at 20 ℃; for 0.166667h;

With tert.-butylhydroperoxide; In toluene; at 0 ℃; for 36h; optical yield given as %ee;

DOI:10.1016/j.tet.2012.04.054

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