ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate

Base Information

• Chemical Name: ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate
• CAS No.: 352555-44-3
• Molecular Formula: C₁₁H₁₂N₂O₃S
• Molecular Weight: 252.294

Synonyms:ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate

Chemical Property of ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate

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Technology Process of ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate

There total 1 articles about ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-phenylacetoacetamide (102-01-2,98624-45-4) + ethyl 3-amino-4-carbamoyl-5-methylthiophene-2-carboxylate (416871-41-5) → ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate (352555-44-3) + ethyl 2,5-dimethyl-4-oxo-2-(N-phenylcarbamoylmethyl)-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-7-carboxylate

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 4h; Heating;

DOI:10.1023/A:1021356603146

Reference yield: 65.0%

ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate (352555-44-3) → 3-benzyl-2,5-dimethyl-4-oxo-3,4-dihydro-thieno[3,4-d]pyrimidine-7-carboxylic acid ethyl ester

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1023/A:1021356603146

Reference yield: 61.0%

ethyl 2,5-dimethyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylate (352555-44-3) → 2,5-dimethyl-4-oxo-3-(p-tolylcarbamoyl-methyl)-3,4-dihydro-thieno[3,4-d]pyrimidine-7-carboxylic acid ethyl ester (352555-60-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1023/A:1021356603146

upstream raw materials:

N-phenylacetoacetamide

ethyl 3-amino-4-carbamoyl-5-methylthiophene-2-carboxylate

Downstream raw materials:

2,5-dimethyl-4-oxo-3-(p-tolylcarbamoyl-methyl)-3,4-dihydro-thieno[3,4-d]pyrimidine-7-carboxylic acid ethyl ester

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