N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Base Information

Chemical Name:N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
CAS No.:1260078-20-3
Molecular Formula:C₂₇H₂₅FN₄O₃S
Molecular Weight:504.585
Hs Code.:

Synonyms:N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

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Chemical Property of N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

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Technology Process of N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

There total 8 articles about N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-(3,8-diazabicyclo[3.2.1]octane-3-carbonyl)phenyl)quinoline-8-sulfonamide

: 459-57-4
4-fluorobenzaldehyde

: 1260078-20-3
N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Guidance literature:: N-(4-(3,8-diazabicyclo[3.2.1]octane-3-carbonyl)phenyl)quinoline-8-sulfonamide; 4-fluorobenzaldehyde; With acetic acid; In dichloromethane; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 50 ℃; for 1h;

Reference yield:

: 18704-37-5
quinoline-8-sulfonyl chloride

: 1260078-20-3
N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 0.17 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 °C

2.2: 0 - 20 °C / Inert atmosphere

3.1: methanol; hydrogenchloride / 1 h

4.1: acetic acid / dichloromethane / 0.5 h

4.2: 1 h / 50 °C

With pyridine; hydrogenchloride; methanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 208175-71-7
ethyl 4-(quinoline-8-sulfonamido)benzoate

: 1260078-20-3
N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 80 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: methanol; hydrogenchloride / 1 h

4.1: acetic acid / dichloromethane / 0.5 h

4.2: 1 h / 50 °C

With hydrogenchloride; methanol; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;