3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

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Chemical Name:3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)
CAS No.:101249-03-0
Molecular Formula:C₃₆H₅₀O₅Si
Molecular Weight:590.875
Hs Code.:

Synonyms:3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

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Chemical Property of 3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

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Technology Process of 3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

There total 1 articles about 3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 72243-94-8
(1S,5R,6R,7R,15S)-7-(tetrahydro-2-pyranyloxy)-6-<(E)-3-hydroxy-1-octenyl>-2-oxabicyclo<3.3.0>octan-3-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 101249-03-0
3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;
DOI:10.1021/jo00359a055

Reference yield:

: 101249-03-0
3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

: 101249-04-1
(3aR,4R,5R,6aS)-4-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 1h;
DOI:10.1021/jo00359a055

Reference yield:

: 101249-03-0
3α,5α-dihydroxy-2β-<3α-((tert-butyldiphenylsilyl)oxy)-trans-1-octenyl>-1α-cyclopentaneacetic acid γ-lactone 3-(tetrahydropyranyl ether)

: 101249-05-2
(Z)-7-[(1R,2R,3R,5S)-2-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-5-hydroxy-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 720 mg / diisobutylaluminium hydride / toluene; hexane / 1 h / -78 °C

2: t-BuOK / tetrahydrofuran / 1 h / Ambient temperature

With potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo00359a055