(4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

Base Information

Chemical Name:(4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide
CAS No.:752211-45-3
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

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Chemical Property of (4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

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Technology Process of (4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

There total 1 articles about (4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 51-66-1
4-methoxyacetanilide

: 98234-53-8
(Z)-4-[(tetrahydropyran-2-yl)oxy]-2-buten-1-yl bromide

: 752211-45-3
(4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

Guidance literature:: 4-methoxyacetanilide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(Z)-4-[(tetrahydropyran-2-yl)oxy]-2-buten-1-yl bromide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/ol049159x

Reference yield: 94.0%

: 752211-45-3
(4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

: 752211-46-4
(4Z)-6-hydroxy-4-hexenoic acid p-methoxyanilide

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 3h;
DOI:10.1021/ol049159x

Reference yield:

: 752211-45-3
(4Z)-6-(tetrahydro-2H-pyran-2-yloxy)-4-hexenoic acid p-methoxyanilide

: (5S)-N-(p-methoxyphenyl)-5-vinylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / p-TsOH / methanol / 3 h / 20 °C

2: 74 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

3: (R,R)-Me-DUPHOS; LiHMDS / Ni(cod)2 / tetrahydrofuran; hexane / 24 h / 20 °C

With pyridine; toluene-4-sulfonic acid; lithium hexamethyldisilazane; [2R-[1(2'R*,5'R*),2a,5b]]-1,1'-(1,2-phenylene)bis[2,5-dimethylphospholane]; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol049159x