(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

Base Information

Chemical Name:(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide
CAS No.:1297604-44-4
Molecular Formula:C₄₅H₆₆N₄O₆Si₂
Molecular Weight:815.213
Hs Code.:

(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

Synonyms:(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

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Chemical Property of (E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

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Technology Process of (E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

There total 1 articles about (E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297604-44-4
(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 7h;
DOI:10.1021/ol200728w

Reference yield:

: 1297604-44-4
(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

: 1297604-45-5
(2R,3S)-2-(4-(benzyloxy)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)-5-((E)-3-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-3-oxoprop-1-en-1-yl)-2,3-dihydrobenzofuran-3-carboxamide

Guidance literature:: With dirhodium(II) tetrakis[(S)-N-phthaloyl-tert-leucinate]; In dichloromethane; at -78 - 20 ℃; for 10h; stereoselective reaction; Molecular sieve;
DOI:10.1021/ol200728w

Reference yield:

: 1297604-44-4
(E)-3-(4-((4-(benzyloxy)benzyl)oxy)-3-(2-((4-((tert-butyldimethylsilyl)oxy)butyl)amino)-1-diazo-2-oxoethyl)phenyl)-N-(4-((tert-butyldimethylsilyl)oxy)butyl)acrylamide

: 1297604-46-6
(2R,3S)-2-(4-(benzyloxy)phenyl)-N-(4-hydroxybutyl)-5-((E)-3-((4-hydroxybutyl)amino)-3-oxoprop-1-en-1-yl)-2,3-dihydrobenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dirhodium(II) tetrakis[(S)-N-phthaloyl-tert-leucinate] / dichloromethane / 10 h / -78 - 20 °C / Molecular sieve

2: ammonium fluoride / acetonitrile / 20 h / Reflux

With ammonium fluoride; dirhodium(II) tetrakis[(S)-N-phthaloyl-tert-leucinate]; In dichloromethane; acetonitrile;
DOI:10.1021/ol200728w