5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

Base Information

Chemical Name:5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione
CAS No.:1390672-65-7
Molecular Formula:C₁₆H₁₃F₃N₄O₃
Molecular Weight:366.299
Hs Code.:

Synonyms:5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

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Chemical Property of 5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

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Technology Process of 5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

There total 14 articles about 5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1000993-88-3
5-allyl-1-methyl-5-pyrimidine-2,4,6-trione

: 1390672-61-3
(4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate

: 1390672-65-7
5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

Guidance literature:: 5-allyl-1-methyl-5-pyrimidine-2,4,6-trione; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Cooling with ice; Inert atmosphere;

(4-methoxyphenyl)-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]iodonium trifluoroacetate; In N,N-dimethyl-formamide; mineral oil; at 40 - 45 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm300631e

Reference yield:

: 81340-56-9
3-(3-iodophenyl)-3-trifluoromethyl-3H-diazirine

: 1390672-65-7
5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium peroxymonosulfate / chloroform / 0 - 20 °C

1.2: 2 h / -10 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice; Inert atmosphere

2.2: 48 h / 40 - 45 °C / Inert atmosphere

With potassium peroxymonosulfate; sodium hydride; In chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300631e

Reference yield:

: C₁₅H₁₁F₃INO₃S

: 1390672-65-7
5-allyl-1-methyl-5-[3-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C

1.2: -20 °C

2.1: potassium peroxymonosulfate / chloroform / 0 - 20 °C

2.2: 2 h / -10 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice; Inert atmosphere

3.2: 48 h / 40 - 45 °C / Inert atmosphere

With potassium peroxymonosulfate; ammonia; sodium hydride; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300631e