6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol

Base Information

• Chemical Name: 6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol
• CAS No.: 860264-46-6
• Molecular Formula: C₄₇H₅₈N₂O₈
• Molecular Weight: 778.986
• Mol file: 860264-46-6.mol

Synonyms:6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol

Chemical Property of 6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol

There total 1 articles about 6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-dec-3-enitol → 6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol (860264-46-6)

Guidance literature:

With sodium acetate; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; at 85 ℃;

DOI:10.1021/jo050494o

Reference yield:

6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol (860264-46-6) → (2S,3R,4S,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-((S)-4-tert-butoxycarbonylamino-4-carboxy-butyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:

With jones reagent; In acetone; at 0 - 20 ℃; for 3.5h;

DOI:10.1021/jo050494o

Reference yield:

6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-D-manno-L-glycero-decitol (860264-46-6) → methyl 6,9-anhydro-7,8,10-tri-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-D-manno-L-glycero-deconate

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone / 3.5 h / 0 - 20 °C

2: diethyl ether; methanol / 0.17 h / 0 °C

With jones reagent; In methanol; diethyl ether; acetone;

DOI:10.1021/jo050494o