(E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester

Base Information

• Chemical Name: (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester
• CAS No.: 78464-48-9
• Molecular Formula: C₁₆H₁₈N₂O₅
• Molecular Weight: 318.329
• Mol file: 78464-48-9.mol

Synonyms:(E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester

Chemical Property of (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester

There total 3 articles about (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(2-Benzyloxycarbonylamino-acryloylamino)-3-hydroxy-butyric acid methyl ester (78464-23-0) → (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester (78464-48-9)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1246/bcsj.54.1132

Reference yield:

Z-threonine methyl ester (3373-59-9,53216-06-1,68331-48-6,79617-28-0,82679-55-8,118525-51-2) → (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester (78464-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / dicyclohexylcarbodiimide (DCC) / dimethylformamide / 12 h / Ambient temperature

2: 65 percent / mesyl chloride, triethylamine / CH₂Cl₂ / 12 h / Ambient temperature

With methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.54.1132

Reference yield:

2-benzyloxycarbonylamino-acrylic acid (39692-63-2) → (E)-2-(2-Benzyloxycarbonylamino-acryloylamino)-but-2-enoic acid methyl ester (78464-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / dicyclohexylcarbodiimide (DCC) / dimethylformamide / 12 h / Ambient temperature

2: 65 percent / mesyl chloride, triethylamine / CH₂Cl₂ / 12 h / Ambient temperature

With methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.54.1132

upstream raw materials:

2-(2-Benzyloxycarbonylamino-acryloylamino)-3-hydroxy-butyric acid methyl ester

Z-threonine methyl ester

2-benzyloxycarbonylamino-acrylic acid