(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Chemical Name:(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester
CAS No.:213487-27-5
Molecular Formula:C₄₈H₄₆N₆O₁₄
Molecular Weight:930.925
Hs Code.:

(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Synonyms:(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Chemical Property of (1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Technology Process of (1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

There total 5 articles about (1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 213487-25-3
Carbonic acid (2R,3S,4R,5R)-4-azido-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester

: 213487-27-5
(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: With triphenylphosphine; In 1,4-dioxane; for 15h; Ambient temperature;
DOI:10.1002/hlca.19980810556

Reference yield:

: 177980-10-8
2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

: 213487-27-5
(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / pyridine / 15 h / Ambient temperature

2: 1.) 2,5-dichlorophenyl phosphorodichloridate, 1H-1,2,4-triazole, pyridine, 2.) 25percent NH₃ / 1.) 16 h, 2.) dioxane, RT

3: 86 percent / DMAP, molecular sieve / CH₂Cl₂ / 72 h / Ambient temperature

4: 47 percent / Ph₃P / dioxane / 15 h / Ambient temperature

With pyridine; 1,2,4-Triazole; dmap; ammonium hydroxide; molecular sieve; 2,5-dichlorophenyl phosphorodichloridate; triphenylphosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1002/hlca.19980810556

Reference yield:

: 173170-12-2
2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil

: 213487-27-5
(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / LiN₃ / dimethylformamide / 16 h / 120 °C

2: 91 percent / pyridine / 15 h / Ambient temperature

3: 1.) 2,5-dichlorophenyl phosphorodichloridate, 1H-1,2,4-triazole, pyridine, 2.) 25percent NH₃ / 1.) 16 h, 2.) dioxane, RT

4: 86 percent / DMAP, molecular sieve / CH₂Cl₂ / 72 h / Ambient temperature

5: 47 percent / Ph₃P / dioxane / 15 h / Ambient temperature

With pyridine; 1,2,4-Triazole; dmap; ammonium hydroxide; molecular sieve; lithium azide; 2,5-dichlorophenyl phosphorodichloridate; triphenylphosphine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19980810556