(3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

Base Information

Chemical Name:(3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one
CAS No.:79985-70-9
Molecular Formula:C₁₈H₂₅FO
Molecular Weight:276.394
Hs Code.:

Synonyms:(3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

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Chemical Property of (3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

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Technology Process of (3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

There total 1 articles about (3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917-54-4
methyllithium

: 79985-69-6
(2E,4E,6E)-2-Fluoro-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienoic acid

: 25576-25-4
(3E,5E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,5-hexadien-1-yne

: 79985-70-9
(3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

: 79994-28-8
(3E,5E,7E)-3-Fluoro-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-ol

Guidance literature:: In diethyl ether; for 4h; -20 deg C -> room temperature;
DOI:10.1021/ja00414a026

Reference yield: 75.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 79985-70-9
(3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

: 79994-26-6
(all-E)-12-fluororetinonitrile

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; for 1.5h; Ambient temperature;
DOI:10.1021/ja00414a026

Reference yield:

: 79985-70-9
(3E,5E,7E)-3-Fluoro-6-methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trien-2-one

: 79994-27-7
(all-E)-12-fluororetinal

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.5 h / Ambient temperature

2: 86 percent / diisobutylaluminium hydride / hexane / 3 h / 0 °C

With diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
DOI:10.1021/ja00414a026