5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one

Base Information

• Chemical Name: 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one
• CAS No.: 103788-94-9
• Molecular Formula: C₂₁H₂₅N₃O₂S₂
• Molecular Weight: 415.58

Synonyms:5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one

Chemical Property of 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one

There total 5 articles about 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-Cyclohexyl-thiazol-4-yl)-ethanol → 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one (103788-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 1 h / Ambient temperature

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

4: NaOAc / ethanol / 3 h / Heating

With copper(I) oxide; hydrogen bromide; hydrogen; sodium acetate; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00092a012

Reference yield:

2-Cyclohexyl-4-[2-(4-nitro-phenoxy)-ethyl]-thiazole (103788-74-5) → 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one (103788-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / methanol / Ambient temperature

2: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

3: NaOAc / ethanol / 3 h / Heating

With copper(I) oxide; hydrogen bromide; hydrogen; sodium acetate; sodium nitrite; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00092a012

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 5-{4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-benzyl}-2-imino-thiazolidin-4-one (103788-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 1 h / Ambient temperature

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

4: NaOAc / ethanol / 3 h / Heating

With copper(I) oxide; hydrogen bromide; hydrogen; sodium acetate; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00092a012

upstream raw materials:

thiourea

4-[2-(2-Cyclohexyl-thiazol-4-yl)-ethoxy]-phenylamine

2-Cyclohexyl-4-[2-(4-nitro-phenoxy)-ethyl]-thiazole

4-Fluoronitrobenzene

Downstream raw materials:

C₂₁H₂₃N₂O₃S₂^(1-)*Na⁽¹⁺⁾

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