N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide

Base Information

• Chemical Name: N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide
• CAS No.: 1443454-21-4
• Molecular Formula: C₁₆H₁₂FNO₂
• Molecular Weight: 269.275
• Mol file: 1443454-21-4.mol

Synonyms:N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide

Chemical Property of N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide

There total 1 articles about N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

inden-1-one (83-33-0) → N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide (1443454-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil / 2 h / 80 °C / Reflux; Inert atmosphere

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.08 h / Inert atmosphere

2.2: 18.5 h / 150 °C / Inert atmosphere

With sodium hydride; In 5,5-dimethyl-1,3-cyclohexadiene; mineral oil;

DOI:10.1002/adsc.201300266

Reference yield: 85.0%

N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide (1443454-21-4) + 3-oxo-1λ3-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile (172876-96-9) → 2-cyano-N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1039/c4ob02032d

Reference yield: 83.0%

N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide (1443454-21-4) + 1-[(trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one → 2-ethynyl-N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide

Guidance literature:

N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide; 1-[(trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201300266

upstream raw materials:

inden-1-one

Downstream raw materials:

2-azido-N-(4-fluorophenyl)-1-oxo-2,3-dihydro-1H-indene-2-carboxamide