Chemical Property of 33-[(E)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Chemical Property:
- Appearance/Colour:Colorless Crystalline Solid
- Vapor Pressure:0mmHg at 25°C
- Melting Point:148-1510 °C
- Refractive Index:1.468
- Boiling Point:1294.741 °C at 760 mmHg
- PKA:13.22±0.70(Predicted)
- Flash Point:736.833 °C
- PSA:275.64000
- Density:1.015 g/cm3
- LogP:4.60370
- Storage Temp.:-20°C Freezer
- Solubility.:Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
- XLogP3:8
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:12
- Rotatable Bond Count:15
- Exact Mass:1215.85701808
- Heavy Atom Count:86
- Complexity:2360
- Purity/Quality:
-
99% *data from raw suppliers
CyclosporinD *data from reagent suppliers
Safty Information:
- Pictogram(s):
F,Xn,T
- Hazard Codes:F,Xn,T
- Statements:
11-20/21/22-36-39/23/24/25-23/24/25
- Safety Statements:
16-36/37-45-7
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O
- Isomeric SMILES:C/C=C/CC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O
-
Uses
Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.